Comparison of Ondansetron and Granisetron for prevention of Postoperative nausea and vomiting (PONV) following laproscopic appendicectomy

Abstract

Introduction: Post-operative nausea and vomiting is the most common and distressing symptom having incidence of 54-92 % in laproscopic surgeries. Ondansetron, a 5HT3 antagonist is the most popular drug used in clinical practice. Other 5HT3 antagonists available are Granisetron, Ramosetron etc., A Prospective randomized study was done on patients undergoing laproscopic appendicectomy under general anaesthesia comparing the efficacy of ondansetron and Granisetron for prevention of Postoperative nausea and vomiting (PONV).

Methods: Sixty patients belonging to ASA I & II undergoing laproscopic appendicectomy under general anaethesia were randomly allocated into two groups. Group A (n =30) received Ondansetron 4 mg (2ml) slow intravenous and group B (n=30) received Granisetron 2 mg (2ml) slow iv.

Results: It was observed that 5 patients (16%) in group A and 2 patients (7%) in group B had nausea and vomiting in immediate post-operative period (upto 6 hr).