Formulation and characterization of maltodextrin based proniosomes of cephalosporins

Abstract

Nowadays, vesicles have become the carrier of choice in drug delivery. Vesicular drug delivery reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. They can incorporate both hydrophilic and lipophilic drugs. In the present study efforts were taken to prepare maltodextrin based proniosomes of cefuroxime axetil. A total of seven formulations were prepared, by varying the surfactant-lipid loading in each formulation. Various evaluation techniques were employed in order to study the performance of the preparations. The micromeritics properties of each preparation were analyzed and they were also subjected to in vitro release study, kinetic data analysis, ex vivo permeation study, stability study etc. From the results of entrapment studies, it could be concluded that the formulation PN4 which is having surfactant: lipid concentration as 1:1 was the best formulation. The SEM image as well as the FT-IR spectrum of the optimized formulation was taken. The mean particle range of proniosomes was between 10.23-22.25µm.