Nephroprotective effect of Vitex negundo linn. on cisplatin induced nephrotoxicity in male albino rats

Abstract

The present study was carried out to investigate the nephroprotective effect of Vitex negundo extract on nephrotoxicity induced by cisplatin in male albino rats. Rats were randomly divided into four groups. Group I was treated as Normal control.  Group II was treated with single intraperitonial dose of cisplatin (16mg/kg body weight) on 1^st day. Group III was treated with single intraperitonial dose of cisplatin on 1^st day which is followed by the oral dose of silymarin (50mg/kg body weight/day) from 2^nd day to 15^th day. Group IV was treated with single intraperitonial dose of cisplatin on 1^st day which is followed by the oral dose of Vitex negundo (200mg/kg body weight/day) from 2^nd day to 15^th day. After 15 days treatment, all rats were sacrificed and collected the blood samples were used for the analysis of biochemical and hematological parameters in all groups and body weights also measured before sacrification of rats. Biochemical results of Vitex negundo treated group showed a decreased in levels of blood urea, uric acid, blood urea nitrogen and creatinine and increased in body weight, albumin and total protein when compared to cisplatin treated groups. Hematological results of Vitex negundo treated group also showed an increased in levels of Hb, RBC, WBC, PCV, MCV and MCHC when compared to cisplatin treated rats. The results of this study were concluded that Vitex negundo protected the rats from the deleterious effects of cisplatin.