Combined effect on antihyperlipidemic activity of Bauhinia variegata (linn.) and Salvadora oleoides (decne.) in Triton WR-1339 induced hyperlipidemic rats

Abstract

Cardiovascular and related illnesses are one of the most common diseases prevalent in many parts of the world. An increased risk of coronary heart diseaseis primarily associated with a high serum total cholesterol and low density lipoprotein (LDL) concentration and a decrease in high density lipoprotein (HDL). The present study was designed to investigate combined effect on antihyperlipidemic activity of butanol extract of leaves of Bauhinia variegata (Linn.) and Salvadora oleoides (decne.) in Triton WR-1339 induced hyperlipidemic rats. Combined dose of butanol extract of leaves of both plant tested for their anti-hyperlipidemic activity. Combined dose of butanol extract administered at a dose of 100 mg/kg (oral) at a ratio 1:1 to the Triton WR-1339 induced hyperlipidemic rats and total cholesterol, triglycerides, HDL, LDL and VLDL level in the blood were checked. Combined dose of butanol extract showed significant reduction (P<0.05) in plasma cholesterol (80.30 mg/dl), triglyceride (98.64 mg/dl), LDL (29.31 mg/dl), VLDL (19.73 mg/dl) and increase in HDL level (31.26 mg/dl) as comparison with standard drug fenofibrate. From the above study it could be concluded that Combined dose of butanol extract of Bauhinia variegata (Linn.) and Salvadora oleoides (decne) not only have resulted in significant reduction in cholesterol, triglyceride, LDL, VLDL level but also increase the HDL level which is good for health.