Antimicrobial and anti-tubercular activity of some new indole derivatives

Abstract

Isatin, an indole derivative, is a versatile compound and has a diversity of applications. In a present investigation, a series of new isatin derivatives (3a-i) were prepared by condensing substituted isatins with benzoyl hydrazides. We designed to investigate new isatin derivatives with the inhibitory effect on bacteria and fungi. The chemical structures of the synthesized compounds were affirmed on the basis of modern analytical technique. The title compounds were evaluated for antimicrobial activity by cup plate method against some selected gram (+) gram (-) bacterial strains, and fungal strains. Preliminary screening was carried out for all the compounds and potent compounds were further evaluated for MIC. Anti-tubercular activity was also determined against Mycobacterium tuberculosis strain H₃₇Rv. The results are promising and show that the compounds are biologically active.