Antimicrobial, Sulphorhodamine (SRB) and Antiviral Evaluation of Cyanoacrylamide Derivatives

Abstract

Antitumor, antiviral, and antimicrobial evaluations were performed on a novel series of acrylamide incorporated benzo[d]thiazole compounds. The structures of these compounds were confirmed by different spectral tools. Most of these compounds except compounds 6 and 7 have high to moderate antimicrobial activity through binding to sterol components of cells or alteration in cell permeability and cell death [1]. Concerning the antitumor activity, the two molecules 5 and 6 exhibit strong cytotoxic effects against human breast cancer (MCF7), human liver carcinoma (HEPG2), and prostate cancer (PC3). It is believed that the cytotoxic effect of these compounds was attributed to different cellular pathways including tyrosine kinase inhibition [2],  tubulin polymerization inhibition, and cell death via apoptosis.    On the other hand, they have showed less toxic effect against the normal HBF4 (normal melanocytes) cells. Antiviral assay was shown for all synthesized compounds. Compounds 4, 5, and 8 exhibit a promising antiviral activity against vesicular stomatitis virus (VSV), while our lead compound 3 show the less viral inhibition in this series.