Retrospective Drug Utilization Review: Potential Drug-Drug Interactions in General Medicine ward of a Tertiary Care Hospital

https://doi.org/10.54037/WJPS.2021.91204

Abstract

Our study was aimed to identify and evaluate the frequency, severity, mechanism and common pairs of Drug-Drug Interactions (DDIs) in prescriptions. The objective was to categorize the drug-drug interactions in prescriptions based on the mechanism involved, to determine the severity of drug-drug interactions in prescriptions, to determine the relationship between number of drugs in the prescription and its potential for drug-drug interactions and to determine the potential drug-drug Interactions with different diagnosis. The data was collected retrospectively and recorded in a data collection form from prescriptions provided in the cases at the Department of General Medicine, Vijaya Group of Hospitals, Vadapalani, Chennai. The study was conducted for a period of 6 months from January to June 2019. Among 150 prescriptions analyzed, a total of 298 drug-drug interactions were found. Majority of drug-drug interactions were of major severity. When analyzed the major mechanism of drug-drug interactions was pharmacodynamic interaction. Under pharmacokinetic drug-drug interactions, interaction through absorption were predominant than other. Our study was conducted in order to determine, analyze the potential drug-drug interactions in general medicine ward of a hospital.