Effect of Combination of Polyherbal Extracts for treatment of Hyperlipidemia using Animal Model

Abstract

Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Coronary heart disease, stroke, atherosclerosis and hyperlipidemia are the primary cause of death. There are mainly two types of hyperlipidemia one is the primary hyperlipidemia caused due single genetic defect, and secondary hypolipidemia is diabetes, myxoedema, nephritic syndrome, chronic alcoholism, with use of drugs like corticosteroids, oral contraceptives, Beta- blockerJustica adhatoda leaves, mimosa pudica leaves, Trigonella foenum-gracecum seeds are traditionally used as antihyperlipidemic drugs as per Ayurvedic literature. Hence the present study is undertaken to investigate the anti hyperlipidemic effect of polyherbal preparation using the above three medicinal plants against high fat diet induced and poloxamer-407 induced hyperlipidemia in rats.