Estimation of Atorvastatin Calcium and Fenofibrate in Human Plasma by UV Spectrophotometric Method

Abstract

An UV spectrophotometric method was developed for the estimation of atorvastatin calcium & fenofibrate in human plasma by using simultaneous equation method. Fenofibrate is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Atorvastatin calcium is a member of the drug class known as statins. It is used for lowering cholesterol. The drug obeyed Beer’s law & showed good correlation near to 0.998. Absorption maxima of atorvastatin calcium & fenofibrate were found to be at 246 and 286 nm respectively. Beer’s law was obeyed in concentration rang of 1-5μg/ml for atorvastatin calcium & 2-10 μg/ml for fenofibrate. The method has been validated for linearity, accuracy & precision. The recovery was more than 99%. The developed method was found to be accurate, simple, precise, economical, and selective for simultaneous estimation of atorvastatin calcium & fenofibrate in tablet dosage form.