Evaluation of Toxicity Profiles of Siddha Preparation of ‘Kabasura Kudineer’ in Laboratory Animals

Abstract

Kabasura Kudineer’ (KSK) is a poly Herbal decoction and well-known one in this series next to Nilavembu kudineer (NVK) from Siddha preparation. This system is most commonly practicing in India especially in southern regions his principle of medicine is proven to contain antiviral compounds it consist of Zingiber, Piper longum, Syzygium aromaticum, Justicia adathoda etc., The formulation was evaluated for acute and chronic toxicity in rats with reference to histopathological, haematological, and biochemical parameters from the various tissues of rats. During acute toxicity study, there were no any adverse effects found in the general behaviour and mortality at any dose level given. In chronic toxicity studies (90days) KSK in various dose level (0.15, 0.75, and 1.5 ml/kg B.wt) did not cause any changes in hematological and biochemical parameters with exception of a transient rise in uric acid, albumin, SGOT and lymphocyte level. The changes observed were significant only at the highest dosage of 1.5 ml/kg B.wt. Excepting albumin level, which increased with average dose (0.75ml), which was not significant when compared to control. Feed and water intake failed to reveal any marked changes in chronic toxicity studies. Histopathological lesions were non-specific in all organs between treated and control group except in liver revealed mild changes with highest dose level. In the present study the drug possessed no toxic effect up to 1.5 ml.