Synthesis and evaluation of pyrazole containing aromatic and heterocyclic derivatives as anti-inflammatory agents

Authors

  • Jalal H. Abdullah Department of Medicinal, Pharmaceutical Organic and Analytical Chemistry, Faculty of Pharmacy, Sana'a University, Sana'a 18084, Yemen
  • Tawfeek A. Yahya Department of Medicinal, Pharmaceutical Organic and Analytical Chemistry, Faculty of Pharmacy, Sana'a University, Sana'a 18084, Yemen
  • Mokhtar Abd-Hafiz Al-Ghorafi Department of Medicinal, Pharmaceutical Organic and Analytical Chemistry, Faculty of Pharmacy, Sana'a University, Sana'a 18084, Yemen

Keywords:

Anti-inflammatory, Carrageenan, Pyrazole, Ibuprofen

Abstract

Series of new compounds containing heterocyclic rings were synthesized and evaluated for their anti-inflammatory activities. 1,3-Diphenyl-1H-pyrazole-4-carbaldehyde (III) was synthesized from 1-phenyl-2-(1-phenylethylidene) hydrazine (II) through Vilsmier-Haack reaction. The compound (III) was reacted with appropriate aromatic/ heteroaromatic amines to generate the corresponding pyrazole derivatives (IV a-f). The structures of synthesized compounds were confirmed using elemental and spectral methods. The anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced rat paw edema assay compared with ibuprofen as a reference. The synthesized compounds (IV a-f) showed moderate activity with % inhibition of edema ranges (45.58-67.32%) when compared to the reference standard ibuprofen (76.45% inhibition).

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Published

2020-10-01

How to Cite

Jalal H. Abdullah, Tawfeek A. Yahya, & Mokhtar Abd-Hafiz Al-Ghorafi. (2020). Synthesis and evaluation of pyrazole containing aromatic and heterocyclic derivatives as anti-inflammatory agents. World Journal of Pharmaceutical Sciences, 8(10), 8–13. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/synthesis-evaluation-pyrazole-anti-inflammatory-agents

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Section

Research Article