Synthesis and evaluation of pyrazole containing aromatic and heterocyclic derivatives as anti-inflammatory agents

Abstract

Series of new compounds containing heterocyclic rings were synthesized and evaluated for their anti-inflammatory activities. 1,3-Diphenyl-1H-pyrazole-4-carbaldehyde (III) was synthesized from 1-phenyl-2-(1-phenylethylidene) hydrazine (II) through Vilsmier-Haack reaction. The compound (III) was reacted with appropriate aromatic/ heteroaromatic amines to generate the corresponding pyrazole derivatives (IV a-f). The structures of synthesized compounds were confirmed using elemental and spectral methods. The anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced rat paw edema assay compared with ibuprofen as a reference. The synthesized compounds (IV a-f) showed moderate activity with % inhibition of edema ranges (45.58-67.32%) when compared to the reference standard ibuprofen (76.45% inhibition).