In vitro and in vivo evaluation of binary Solid dispersion of Curcumin by solvent evaporation technique

Abstract

Curcumin, a natural pigment extracted from the plant curcuma longa, had wide range of pharmacological activities. However, its limited aqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions were prepared with the objective of solu­bility and dissolution enhancement of curcumin using polyethylene glycol (PEG 4000)-polyvinylpyrrolidone (PVP K 30) combination carrier by solvent evaporation technique. Solid dispersions of curcumin in different ratios with Polymers were prepared and evaluated for its saturation solubility, drug content, flow properties, in vitro, in vivo by HPTLC method and Physical characterization by IR, DSC, and studies, in comparison with corresponding physical mixtures and drug. Studies revealed the changes in solid state during the formation of dispersion and justified the formation of high-energy amorphous phase from crystalline state of curcumin.