Formulation Development with Box-behnken design Study of Ondansetron HCl Ethosome for chemotherapy induced nausea vomitting

Abstract

Aim of this work was evaluation of Ethosome by box-behnken design study of Ondansetron HCl Ethosome for physicochemical characterization was carried out by scanning electron microscopy, zeta sizer, particle size analyser and freeze fracture performed. Ethosomes shown a higher % EE greater ability to deliver entrapped drug because of ethonol effect. The optimized batch of Ethosome has zeta potential of -24 mv, vesicle size was found to 242.3nm (PDI = 0.245). In-vivo release study performed using Guinea pig skin through Franz’s cells for (24 hr). Ethosome shows higher flux by Hyton and chains analysis. Gel prepared by using Carbopol 940 shows pesudoplastic flow. Ondansetron HCl undergoes first-pass metabolism, so its bioavailability may be improved when delivered through transdermal route. The 3-D response plots were constructed from linear model obtained from the regression analysis through Design Expert®. ANOVA on the basis of p-value was found to be less than 0.05 at 95% Confidence limit by student-t test.