Formulation and characterization of maltodextrin based proniosomes of cephalosporins

Authors

  • Preethy Cheriyan Department of Pharmaceutics, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India
  • Boby Johns George Department of Pharmaceutics, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India
  • Noby Thomas Department of Pharmaceutics, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India
  • Praveen Raj Department of Pharmaceutics, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India
  • Jeny Samuel Department of Pharmaceutics, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India
  • Sr. Betty Carla Principal, St. Joseph’s College of Pharmacy, Cherthala, Kerala, India

Keywords:

Cefuroxime axetil, Proniosome, Slurry method, in vitro drug release, ex vivo absorption study, SEM, stability study.

Abstract

Nowadays, vesicles have become the carrier of choice in drug delivery. Vesicular drug delivery reduces the cost of therapy by improved bioavailability of medication, especially in case of poorly soluble drugs. They can incorporate both hydrophilic and lipophilic drugs. In the present study efforts were taken to prepare maltodextrin based proniosomes of cefuroxime axetil. A total of seven formulations were prepared, by varying the surfactant-lipid loading in each formulation. Various evaluation techniques were employed in order to study the performance of the preparations. The micromeritics properties of each preparation were analyzed and they were also subjected to in vitro release study, kinetic data analysis, ex vivo permeation study, stability study etc. From the results of entrapment studies, it could be concluded that the formulation PN4 which is having surfactant: lipid concentration as 1:1 was the best formulation. The SEM image as well as the FT-IR spectrum of the optimized formulation was taken. The mean particle range of proniosomes was between 10.23-22.25µm. 

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Published

2015-01-02

How to Cite

Preethy Cheriyan, Boby Johns George, Noby Thomas, Praveen Raj, Jeny Samuel, & Sr. Betty Carla. (2015). Formulation and characterization of maltodextrin based proniosomes of cephalosporins. World Journal of Pharmaceutical Sciences, 3(1), 62–74. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/formulation-maltodextrin-based-proniosomes-cephalosporins

Issue

Section

Research Article