A new validated method for the estimation of pregabalin and etoricoxib an using high performance liquid chromatography and of its degradation
Keywords:Excision, Phytochemicals, Tetrapleura tetraptera, Re-epithelilization, Alloxa monohydrate
A easy, exact, accurate, and long-lasting reverse phase RP-HPLC technique has been developed and validated for the simultaneous quantification of Pregabalin and Etorcoxib in bulk and formulation. This procedure employs a simple isocratic mobile phase of acetonitrile, a 150 x 4.6 mm, 2.7 m ascentis C18 column, with a flow rate of 0.8 ml/min of 0.01N Potassium dihydrogen phosphate (50:50). Average retention durations for pregabalin and etoricoxib were 2.313 and 2.840 minutes, respectively. Pregabalin and etoricoxib's percentage recovery were found to be 100.24% and 99.98%, respectively, showing that the approach is appropriate for routine analysis. With an R2 of 0.999 for all drugs, it was shown that Pregabalin and Etorcoxib are linear, demonstrating the approach's potential for producing results with high sensitivity. The% RSD should not exceed 2.0%, showing that the procedure is exact, according to the precision acceptance standards.
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Copyright (c) 2022 E.S.N Sumithranandan, Makula Ajitha
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