Reduction of cardiac effect of propranolol in lisinopril treated isolated rabbit heart

Authors

  • Hina Abrar Dow College of Pharmacy, Dow University of Health Sciences, Karachi. Faculty of Pharmacy, Baqai Medical University, Karachi, Pakistan
  • Hina Yasin Dow College of Pharmacy, Dow University of Health Sciences, Karachi. Faculty of Pharmacy, Baqai Medical University, Karachi, Pakistan
  • Shaukat Khalid Faculty of Pharmacy, Baqai Medical University, Karachi, Pakistan
  • Rehana Perveen Faculty of Pharmacy, Baqai Medical University, Karachi, Pakistan
  • Hina Tabassum Dow College of Pharmacy, Dow University of Health Sciences, Karachi.
  • Kaneez Fatima Faculty of Pharmacy, Baqai Medical University, Karachi, Pakista

Keywords:

Pharmacodynamic interaction, Langendroff’s technique, negative ionotropic, negative chronotropic

Abstract

Background; Angiotensin converting enzyme inhibitors are widely used in hypertensive patients who may come across to a condition which require emergency treatments.

Objective: Pharmacodynamic interaction of Propranolol and Lisinopril was assessed in this study with variable exposure of myocardium according to time.

Materials and methods: 20 healthy male rabbit divided in two groups were selected for the study.  Lisinopril was given in a dose of 10mg/kg orally for 9 days. The effects of Propranolol were determined on isolated hearts by using Langendroff’s technique.

Result: The negative ionotropic effect of Propranolol were significantly decreased (P<0.05).The negative chronotropic effect of low dose was significant (P<0.05) while at high dose the effect was insignificantly decreased (P>0.05).

Conclusion: The response of propranolol is reduced in lisinopril treated heart.

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Published

2018-01-02

How to Cite

Hina Abrar, Hina Yasin, Shaukat Khalid, Rehana Perveen, Hina Tabassum, & Kaneez Fatima. (2018). Reduction of cardiac effect of propranolol in lisinopril treated isolated rabbit heart. World Journal of Pharmaceutical Sciences, 6(1), 24–28. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/reduction-cardiac-effect-propranolol-lisinopril

Issue

World J Pharm Sci 2018; 6(1): 1-46

Section

Research Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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