The relation between Hormonal disturbances, Liver enzymes and Body Mass Index in Selected Cases of Polycystic Ovarian Syndrome in Iraqis Women

Abstract

Polycystic Ovarian Syndrome (PCOS) is a common disorder affecting up to 21% of women of childbearing age, thought to be primarily a reproductive disorder. Objective: To evaluate free testosterone, glucose. Total cholesterol, triglyceride, liver enzymes, thyroid hormones and prolactin in overweight PCOS Iraqi women compared with healthy lean women as a control group. Materials and Methods: This was a case-control study carried in Al-Imamaien Al-Kathumain hospital, Baghdad, Iraq; between June 2014 and December 2015. The study included 75 female patients suffering from PCOS. The age of involved patients was 22 - 44 years (32.610 ± 5.696 years). Control group was consisted of 30 healthy volunteer females, whose mean ages were matched (30.140 ± 5.198 years). Results: Our data showed that PCOS overweight women with general clinical signs of hyperandrogenism tended to have a higher BMI than healthy lean women 26.8 ± 4.6 (kg/m2) P <0.05, and total testosterone showed significant elevation 2.08±0.68 (nmol/L) P ‎<0.05. Our data showed there were a significant increase in mean ± SD of serum level of glucose 95.00 ± 12.7(mg/dl), total cholesterol‎ 187.0 ±50‎ (mg/dl), triglyceride 79.5 ± 30.5(mg/dl) p<0.001 respectively, AST ‎19.14 ± 8.5(U/L), ALT‎ 16.22 ± 4.5‎ (U/L) p<0.05, TSH 3.4 ± 1.2 μIU/ml, T4 9.5 ± 2.5μg/dl, T3 2.6 ± 0.8 ng/ml p <0.01 and prolactin‎ 27.00 ± 4.5 ng/ml p<0.001 in women with polycystic ovarian syndrome compared with healthy women. Discussion: In adult women with hirsutism and PCOS, obesity is associated with increased total testosterone and decreased SHBG, which results in significantly elevated free and bioavailable testosterone. Conclusion: The greater the BMI the more frequent the presence of steatosis, most of obese women had nonalcoholic fatty liver disease (NAFLD).