A review on analytical methods for determination of oral anti-diabetic drugs like biguanides, gliptins and gliflozins in bulk and in pharmaceutical dosage forms

Abstract

The aim of this review to focus on a comprehensive update of different analytical methods for determination of oral anti-diabetic drugs for the treatment of type 2 diabetes mellitus (T2DM), such as biguanides, dipeptidyl peptidase 4 inhibitors (gliptins), and sodium/glucose co-transporter 2 inhibitors (gliflozins) in their bulk materials and in pharmaceutical dosage forms. The review entails about analytical procedures like RP-HPLC, HPLC-UV, TLC/HPTLC and spectrophotometric (UV/VIS) methods taken from the literature over the past ten years (2007-2017). This review provides detailed information of estimation and separation conditions for biguanides, gliptins and gliflozins in alone or in combination with or without presence of their impurities and their degradation products.