Evaluation of anti-gastric cancer of ethanol extract of calycophyllum spruceanum against methyl niroso ureas-NaCl induced gastric cancer in experimental rats

https://doi.org/10.54037/WJPS.2022.100102

Abstract

Cancer starts with a change in one single cell. This change may be initiated by external agents and genetic factors. one of the leading diseases is found to be cancer, worldwide and affecting 7.6 million deaths in 2008.  Mortality rate is majorly due to   Lung, stomach, liver, colon and breast cancer. Epidemiology results the second most mortality rate is due to Gastric cancer. the primary preventive measure is increasing the standards of hygiene with significant nutrition. early detection can decrease risk for cancer. The primary treatment for gastric cancer is surgery by standardized lymphadenectomy. The present research focuses on calycophyllum spruceanum for screening of gastric cancer against methyl nitroso ureas and NACL induced gastric cancer in albino rats. Cancer is induced in rats by using nitroso urea and test group is treated with herbal extracts of different doses 100, 200 and 400 mg/kg. The animals are screened for enzymes namely AST, ALT, tissue peroxidase, reduced glutathione, catalase and stomach tissue microscopic study. Results proved that the plant have gastric cancer activity.