Myoinositol plus D-chiroinositol combination versus metformin on hirsutism in patients with polycystic ovarian syndrome

Abstract

Polycystic ovary syndrome is most commonly associated with hirsutism. Weight loss or pharmacologic interventions that lower insulin levels reduce androgen levels and improve menstrual cycle patterns in many of these women hence the study was planned specifically to evaluate the efficacy of metformin versus myoinositol plus d-chiroinositol combination therapy in hirsute PCOS patients. Newly diagnosed PCOS patients from the department of Obstetrics and Gynaecology, GMC Amritsar, were enrolled and randomly divided into 2 groups of 25 each. Group 1 were given metformin 500 mg twice daily and group 2 were given myoinositol plus d-chiroinositol combination therapy 1000 mg twice daily for 9 months. Follow up was done at 3, 6, 9 months. At each visit, serum testosterone levels and Modified Ferriman-Gallwey score were evaluated. Informed consent was taken from all the patients. The percentage change from baseline in serum free testosterone levels (22.46±6.47) and mean Modified Ferriman Gallwey score (33.85±3.92) showed statistically significant decrease in group 2 (p value<0.05). It was observed that both treatments improved hirsutism but the results were statistically significant in myoinositol and d-chiroinositol group.