Development and evaluation of long circulating Vitamin E TPGS coated docetaxel liposomes for I.V. administration

Abstract

In the preparations of Docetaxel liposomes which are coated with p-alpha-tocopheryl polyethylene glycol succinate (TPGS), which is a good targeting agent for tumor, amphiphilic vitamin E TPGS which is a quite stable under normal condition as compared to PEG coated liposomes. Docetaxel coated liposomes were prepared by solvent hydration method and they are characterized for their entrapment efficacy, zeta potential and pharmacokinetic studies. Docetaxel coated liposomes were also observed under microscope which observed very clear, small, vascular like liquid, long circulating liposomes Vitamin ETPGS Coated liposomes were used because they directly target the tumor and protect the engulfment through Endoplasmic reticulumn and prevent the binding through protein and albumin. While performing the study preformulation studies were carried out such as spectrophotometric studies, solubility and p-ka studies were obtained. Long circulating liposomes coated with PEG, increase the stability of the liposomes in the blood & protect its engulfment through EPR protein binding. In the development of vitamin ETGPS coated liposomes various chemical were used like lipoid E80, cholesterol, methanol, chloroform was used and at the end   liposomes were coated with ETPGS. Docetaxel was extracted from taxoid family of anti-neoplastic drug. TPGS coated liposomes showed great advantages in vitro than PEG coated liposomes. Study confirms that solvent hydration method is suitable for the docetaxel liposomes.