Anti-Hyperlipidemic activity of murraya koenigii leaves extract against fructose induced hyperlipidemia

Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. A literature claimsthat flavonoids can able to reduce the hyperlipidemia. The literature available on Murraya koenigii Leaves suggested for the presence of flavonoid content, therefore the leaves of Murraya koenigii were selected and the present study was designed to investigate theanti-hyperlipidemicactivity of extract of Murraya koenigii fructose induced Hyperlipidemia. Murraya koenigii was administered at a dose of 100mg/kg and 200mg/kg per day, (p.o) to fructose induced Hyperlipidemic rats. Atorvastatin was used as reference standard.The statistical analysis was carried out using one way ANOVA followed by Tukey test. Murraya koenigii showed a significant decrease in the levels of serum cholesterol, triglycerides, LDL, VLDL and a gradual increase in the level of serum HDL at the dose of 200mg/kg/day (p.o) against fructose induced hyperlipidemia. Therefore the study concluded that the extract of leaves of Murraya koenigii effectively suppressed the hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.