PREPARATION AND EVALUATION OF SAFINAMIDE ORAL THIN FILMS

Abstract

A fast-dissolving medicine delivery system provides a solution for people who experience trouble swallowing pills or capsules. This research aims to generate oral thin films of Safinamide via the solvent casting process. Oral thin films were made utilizing several super disintegrants, such as lycoat and crospovidone, in varying ratios alongside gelatin and polyvinyl alcohol as film-forming agents. The formulated films were assessed for film thickness, folding endurance, in-vitro disintegration time, and in-vitro drug release profile in pH 6.8 phosphate buffer. Investigation of drug content and drug-polymer interactions using infrared spectroscopy. Among all formulations, formulation F12, made with 450 mg of crospovidone, exhibited favorable drug release (99.34±1.25%).