FORMULATION AND IN VITRO EVALUATION OF EZOGABINE ORAL THIN FILMS

Abstract

Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules. The present research work is to develop oral thin films of Ezogabine by using solvent casting method. Oral thin films were developed by using various super disintegrants like Lycoat and Ludiflash in different concentrations with Gelatin, Poly vinyl alcohol as a film forming agents. The prepared formulations of films were evaluated for film thickness measurement, folding endurance study, in-vitro disintegration time, in-vitro drug release pattern (in pH 6.8 phosphate buffer). Drug content, and drug-polymers interaction study (IR spectroscopy). Among all formulations, the formulation (F12) prepared by 450mg of Lycoat show good drug release (99.37±1.45%).