PREPARATION AND EVALUATION OF LESINURAD NANOSPONGES BY USING SOLVENT EVAPORATION METHOD

Abstract

In this study Lesinurad Nanosponges were prepared by the solvent evaporation technique. The Nanosponges formulations were prepared by solvent evaporation method employing HPMC K4, Carbopol 934, Sodium Alginate rate retarding polymers using PVA as a co polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, percentage yield, and drug entrapment efficiency of Nanosponges were examined. Shape and surface morphology of the Nano sponges were examined using scanning electron microscopy. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges. SEM photographs revealed the spherical nature of the Nano sponges in all variations; however, at higher ratios, drug crystals were observed on the nano sponge surface. Increase in the drug/polymer ratio which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased. The particle size was found in the range of 500 to 680 nm. The entrapment efficiency of different formulations was found in the range of 57.16±1.35% to 78.12±1.33%. The in vitro release studies revealed that the formulation with higher concentration of penetration enhancer showed greater drug release.