FORMULATION AND EVALUATION OF RILPIVIRINE NANOSUSPENSION BY NANO PRECIPITATION METHOD

Abstract

The aim of the present work is to develop oral Nanosuspension of Rilpivirine by Nano Precipitation method using various Stabilizers & Surfactant such as β-cyclodextrin, Soluplus, Poloxamer 407, Polyvinyl alcohol, Sodium lauryl sulfate, Polysorbate 80 Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared Nanosuspension was done with respect to Drug Content, Percentage yield, Entrapment efficiency, Viscosity, Sedimentation volume, Scanning electron microscopy, Particle’s size, zeta potential, dissolution rate, in-vitro dissolution study. Zeta potential value for the optimized formulation (NS12) was found to -4.49 mv which was found to be within the acceptable limits. Average particle size of Nano suspension of optimized formulations (NS12) which is in ratio with Poloxamer 407 was found to be 500.4 nm. From the In vitro studies we can say that formulation NS12 shows best drug release of 98.42±1.27% within 30 minutes whereas all the other formulations didn’t release the drug. The drug release from the Nanosuspension was explained by the using mathematical model equations such as zero order, first order, and equation methods. Based on the regression values it was concluded that the optimized formulation NS12 follows first order kinetics with super case-II transport mechanism and the stability studies shows that the formulation was stability upto 3Months of time period.