FABRICATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF GLIPIZIDE

Abstract

The aim of this investigation is to style oral doubly a daily sustained unleash matrix tablets of Glipizide 10mg, used for the treatment of anti-diabetic drug from the antidiabetic drug category which might unharness the drug for ten hours. The tablets were ready by the Wet granulation technique mistreatment variable concentrations of sustained unharness polymers HPMC, Eudragit. The compatibility of the polymers was dominated out by FT-IR studies and located to be compatible. Total nine formulations were ready. The Glipizide powder and also the powder- blends of tablets were evaluated for their physical properties like angle of repose, bulk density and sponginess index and located to be smart and satisfactory. The manufactured tablets were evaluated for in method and finished product internal control tests as well as look, dimensions, weight variation, hardness, friability, drug content, and in vitro drug unleash. The dissolution medium used was hydrogen ion concentration half dozen.8. phosphate buffer. All formulations showed acceptable pharmaco-technical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated all formulations free up to 10hours and formulation containing HPMC: F3 was the foremost successful formulation with 99.38% drug unharness at the tip of ten hours.