A Systemic Review on: FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLET

Abstract

The development of gastroretentive tablets marks a significant step forward in oral drug delivery methods, particularly for medicines having limited absorption windows in the upper gastrointestinal tract, low solubility in alkaline pH, or local stomach activity. Gastroretentive drug delivery systems (GRDDS) are intended to increase the gastrointestinal residence duration of dose forms, boosting bioavailability, lowering dosing frequency, and increasing patient compliance. This comprehensive review focuses on the many formulation options for gastroretentive tablets, including floating, mucoadhesive, swelling, high-density, and magnetic systems. The selection of suitable polymers, excipients, and technologies is crucial to achieve the necessary gastroretentive characteristics. The review also delves into assessment characteristics such as floating lag time, total floating duration, swelling index, hardness, friability, medication content, and in vitro release tests. Furthermore, in vivo imaging and pharmacokinetic investigations are critical for determining gastroretentive behavior and treatment effectiveness. This study seeks to give a complete understanding of the current methodologies and assessment methods used in the creation of successful gastroretentive tablets, ultimately leading to superior therapeutic outcomes for targeted drug administration in the stomach.