FORMULATION AND EVALUATION OF TENOXICAM GASTRORETENTIVE TABLET

Abstract

The present study successfully developed and evaluated Tenoxicam gastroretentive floating tablets aimed at providing sustained drug release and prolonged gastric retention. The preformulation and post-compression parameters confirmed the suitability of the excipients and ensured consistent tablet quality with acceptable flow properties, mechanical strength, and uniform drug content. FTIR studies indicated no significant drug-excipient interactions, affirming chemical compatibility. The in-vitro buoyancy studies demonstrated efficient floating behavior with prolonged retention over 10 hours, essential for effective gastroretentive delivery. Among all batches, formulations such as F5 and F6 exhibited optimal physicochemical and performance characteristics, making them promising candidates for further in-vivo studies and potential commercial formulation development.