SOLUBILITY ENHANCEMENT OF ORNIDAZOLE BY COMPLEXATION WITH BETA CYCLODEXTRIN.

Abstract

This research explores the formulation of fast dissolving tablets enriched with beta cyclodextrin (β-CD) to augment dissolution characteristics. Beta cyclodextrin β-CD, a cyclic oligosaccharide, offers a unique molecular cavity that accommodates drug molecules, thereby enhancing their solubility and bioavailability. Various formulations were prepared and assessed for parameters including disintegration time, dissolution rate, and drug content uniformity. Results demonstrate that the inclusion of β-CD significantly improves dissolution rates, leading to enhanced drug release compared to conventional tablets. Optimized formulations exhibit rapid disintegration, facilitating swift drug delivery.