FORMULATION AND IN VITRO EVALUATION OF VILAZODONE ORAL THIN FILMS

Abstract

Fast dissolving medication delivery systems provide a solution for individuals who have difficulties swallowing tablets/capsules. The current study aims to generate oral thin films of Vilazodone utilizing the solvent casting process. Oral thin films were created by combining several super disintegrants such as Lycoat and Ludiflash in varying concentrations with PVA and Gelatin as film formation agents. The film formulations were tested for film thickness measurement, folding endurance, in-vitro disintegration time, and in-vitro drug release pattern (in pH 6.8 phosphate buffer). Drug content and drug-polymer interaction analysis (IR spectroscopy). The formulation (F12) containing 45 mg of Ludiflash demonstrated effective drug release (99.28±1.46%) within 10 minutes.