FORMULATION AND EVALUATION OF DAPSONE NANOSPONGES BY SOLVENT EVAPORATION METHOD

Abstract

In this study Nano sponges were prepared by the solvent evaporation technique and subsequently formulated in a gel form of Dapsone. The Nanosponges formulations were prepared by solvent evaporation method employing β-Cyclodextrin, Ethyl Cellulose and Pluronic F127 rate retarding polymers using PVA as a co polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size and drug entrapment efficiency of Nano sponges were examined. Shape and surface morphology of the Nano sponges were examined using scanning electron microscopy. Scanning electron microscopy revealed the porous, spherical nature of the Nanosponges.SEM photographs revealed the spherical nature of the Nano sponges in all variations; however, at higher ratios, drug crystals were observed on the nano sponge surface. Increase in the drug/polymer ratio (1:1 to 1:2) which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased. The particle size was found in the range of 200-350 nm. The entrapment efficiency of different formulations were found in the range of 62.49±1.47% to 77.51±1.81%. The in vitro release studies revealed that the formulation with higher concentration of penetration enhancer showed greater drug release and it follows the Zero order drug release with Super case II transport mechanism.