Microwave energy a novel approach in solubility enhancement: A review

Abstract

The development of any pharmaceutical dosage forms starts with the Preformulation studies; Preformulation studies focuses on the physicochemical properties of drug candidate that could affect the drug performance and can define various critical attributes in development of potential dosage form. Out of the various parameters considered in Preformulation studies, solubility remains the most important aspect when it comes to the lower bioavailability of the drug candidate. Out of the all NCE’s 40% of the drug candidates lacks the solubility which potentially accelerate the need of solubility enhancement of the drug. Many attempts and practices have made in order to increase solubility of the drug which involves use of certain organic solvents, some mechanical processes, Co-solvency approach etc. Green chemistry is a sustainable chemistry which is used in product or processes that will eliminate the use and generation of hazardous products. Microwave technique generally required no use of any solvents or any mechanical process, in this review article an attempt was made to enlighten the potential use of microwave technique which can be utilized in pharmaceutical industry.