Evaluation of anti-diabetic and anti-hyperlipidemic activity of Psidiumguajavaseeds in type-2 diabetic rats

Authors

  • M.V. Kiran Kumar CMR College of Pharmacy, Hyderabad, Telangana
  • Sandhya V CMR College of Pharmacy, Hyderabad, Telangana
  • G.S.N. Koteswara Rao K L College of Pharmacy, KLEF Deemed to be University, Vaddeswaram, Guntur, Andhra Pradesh

Keywords:

Diabetes mellitus, Hyperlipidemia, Psidium guajava (PG), Streptozotocin (STZ)

Abstract

The study was designed to evaluate the anti-diabetic and anti-hyperlipidemic activity of Psidium guajava seeds in normal and streptozotocin (STZ) induced type-2 diabetic rats. The ethanolic extract of Psidium guajava was characterized and tested in Wistar rats. The selected rats were divided into four groups. Type-2 diabetes was induced by STZ 30 mg/kg body weight through intravenous (i.v.) route. Oral administration of ethanolic extract of Psidium guajava seeds extract (400mg/kg body weight/day) for 4weeks to STZ induced diabetic rats significantly decreased the levels of blood glucose, HDL, LDL, triglycerides (TG) and cholesterol.

Downloads

Published

2019-02-01

How to Cite

M.V. Kiran Kumar, Sandhya V, & G.S.N. Koteswara Rao. (2019). Evaluation of anti-diabetic and anti-hyperlipidemic activity of Psidiumguajavaseeds in type-2 diabetic rats. World Journal of Pharmaceutical Sciences, 7(2), 133–136. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/anti-diabetic-anti-hyperlipidemic-activity-psidium-guajava-seeds

Issue

World J Pharm Sci 2019; 7(2): 46-136

Section

Research Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.