Antimicrobial Screening Tests of Boric acid with Fluoroquinolones or Meropenem in some ophthalmic preparations

Abstract

The aim of this study is to prepare boric acid ophthalmic solution with antibiotic to treat the mild infections. In this study four ophthalmic formulas were prepared containing boric acid alone or combination with fluoroquinolone (moxifloxacin) or meropenem and screening some properties as well as screening tests for their antibacterial activities in vitro against Gram positive and Gram-negative bacteria using gatifloxacin formula as a reference. The purpose of using boric acid is common to treat the mild infections caused by a bacterial or fungal infection of the external eye local therapy. The use of combination therapy with moxifloxacin as potent antibiotic in the treatment of bacterial conjunctivitis. Docking of boric acid with two different types of bacteria, compare some physical and chemical properties and stability study of boric acid at four different temperatures (formula 1), as well as the screening tests for their antimicrobial activities in vitro against Gram positive and Gram-negative bacteria using gatifloxacin and glycerin as references.