Comparison of antipyretic effectiveness between standard drugs with different doses of Ocimum sanctum linn (Tulsi)

Abstract

Background: Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects. Yet to date there are very few studies pertaining to the antipyretic activity. Objective: To compare the anti-pyretic property of aqueous form of Ocimum Sanctum Linn (tulsi) fresh leaves, in different doses with that of standard drug, in experimentally induced acute fever in   animal models. Methodology: Adult Wistar Albino Rats of both sex weighing 125-150 grams were randomly divided into 3 groups (n=6); First group were the standard drug (control) subjects (Paracetamol 100 mg/kg), the second and the third groups were the test group (Tulsi 400mg/kg & 800mg/kg). After recording the initial temperature, fever was induced by injecting 15% of brewer’s yeast. 18 hrs post challenge, each rat was fed orally with standard and test drugs respectively. Temperature was recorded at basal level, and at 30, 60, 120 and 180 minutes respectively. Results: There was a statistically significant reduction of temperature in the tulsi treated group. Conclusion: Fever control was comparable with that of standard drug.