Formulation and evaluation of Mefenamic acid solid dispersions

DOI: https://doi.org/10.54037/WJPS.2021.9902

Abstract

The main objective of this study was to prepare and evaluate solid dispersion of Mefenamic acid, to enhance the dissolution rate, solubility & bioavailability. Mefenamic acid solid dispersion were prepared using Poly vinyl Pyrrolidone (PVP K 30) and Poly Ethylene Glycol (PEG 4000) as hydrophilic carriers by solvent evaporation and kneading techniques. FTIR studies showed that there was no interaction between the drug and polymer.  The prepared Solid dispersion KM3(1:3) using PVP K30 showed minimal wetting time of 14 seconds compared with the other formulations. In vitro release studies in Phosphate buffer pH of 7.4 revealed that the solid dispersions prepared by kneading method showed faster drug release compared with solvent evaporation method.  So, the dissolution profile of solid dispersion containing PVP K30 (1:3) by kneading method was selected as the best formulation because of its faster drug release among all formulations. The development of solid dispersion of Mefenamic acid could be a promising approach to enhance its dissolution rate, solubility and bioavailability.