Formulation and In-vitro evaluation of transdermal patch of Lornoxicam by using hydrophilic and hydrophobic polymers

Abstract

The purpose of this work is to develop and evaluate matrix-type transdermal patch containing drug Lornoxicam with different ratios of hydrophilic (PVA) and hydrophobic (Ethyl cellulose) polymeric systems, in which 4 % w/v of Tween 80 as penetration enhancer and 10 % w/v of PEG 400 as plasticizer in dichloromethane and methanol (4:1) solvent system by using Solvent Evaporation Technique. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, tensile strength, folding endurance, percentage moisture loss, percentage moisture uptake, and water vapour transmission rate. Drug excipients compatibility studies are confirmed by using FTIR Spectrums. In-vitro permeation studies of formulations were prepared by using Franz diffusion cells. Mechanism of drug release was determined by Korsmeyer-Peppas equation. The ‘n’ values were found in the range of 0.836-1.159. It indicated that the formulation follows diffusion mechanisms of both non-Fickian and super case II transport. The kinetic studies showed that, formulation F-1 follow zero order while formulations F-2 to F-7 follow fist order. These results indicate that the formulation F3 {poly vinyl alcohol: Ethyl cellulose (1:1)} has shown optimum release of 79.34% with its action sustained for 24 hours time period.