Inhibitory property of aqueous extract of Ricinus communis leaves on proliferation of melanoma treated against A375 cell lines

Abstract

Some medicinal plants are a root of new drugs in order to hunt for the treatment of melanoma cancer whose treatment is still a big confront to the whole world. This study was intended to evaluate the anti-tumor activity of aqueous extract of Ricinus communis leaves on the human melanoma cancer cell lines (A375). The percentage viability of cancer cell lines was carried out by using trypan blue dye exclusion method and cytotoxicity assay was screened by applying MTT [3-(4, 5-Diamethylthiazol-2-yl)-2, 5-Diphenyl tetrazolium Bromide] assay. Ricinus communis aqueous extract has depicted momentous and potent cytotoxic effect on A375 cell lines with IC₅₀ 48µg/ml in concentration ranging between 25μg/ml to 100μ/ml and acted as best agent to reduce the number of cancer cells to minimum. Therefore impending growth inhabiting activity of aqueous extract should be well thought-out for further phytochemical analysis and marker compound identification, so that it should be used for promoting expansion as a cancer therapeutic agent against human melanoma cancer cell lines alone or adjuvant to other chemotherapeutic drugs.