Effect of alcoholic extract of terminalia bellirica roxb. in acetic acid induced colitis

Abstract

To evaluate the effectiveness of alcoholic extract of Terminalia bellirica Roxb.(TBAE) in acetic acid induced colitis. Standard drug and extract administered for 9 days. Experimental colitis was induced on 8^th day by giving mice intra-rectal administration of 0.1 ml 6% (v/v) acetic acid using catheter under local anesthesia and using liquid paraffin as lubricant. The animals were sacrificed 24 h after the last dose administration, Disease parameters was studied. Disease activity index, macroscopic score, microscopic score, MPO and colon length were showed recovery of disease with significant effectiveness in 100 mg/kg dose, 250 & 500mg/kg dose and Mesalamine (100 mg/kg dose). TBAE shows effectiveness in dose dependent manner. TBAE 500 mg/kg provides better protection and is comparable to the standard drug- Mesalamine