Comparative evaluation of antimicrobial efficacy of curcumin nano suspension and curcumin suspension using agar diffusion method: An invitro study

Abstract

Poor water solubility and slow dissolution rate a major disadvantage of conventional formulation has been over comed by Nano drug delivery system. The aim of the present study was to develop a method for the preparation of nanoparticles of curcumin with a view to improve its aqueous-phase solubility and examine the effect on its antimicrobial properties. Nanosuspension of curcumin was prepared in two formulations with a varying ratio of by Solvent evaporation method, characterized for their anti microbial activity. Of the two formulations, F2 formulation is having greater drug content, greater invitro drug release thus greater anti microbial activity against gram positive and gram negative formulation.