FORMULATION AND EVALUATION CARBAMAZEPINE BILAYER TABLET

Abstract

Gastro-retentive medication delivery methods are extensively utilized to extend the retention of dose forms in the stomach. The floating bilayer tablet formulation provides sustained drug release and extended stomach retention, in addition to the benefits of a liquid oral dose form. This study aimed to formulate and assess floating bilayer tablets of Carbamazepine utilizing various polymers, including Lycoat and Crospovidone as superdisintegrants, and Xanthan Gum and Carbopol 934P as extended-release polymers, alongside additional substances such as Magnesium stearate, Sodium bicarbonate, citric acid, Talc, PVP K30, MCC, and Lactose. The fabricated bilayered tablets were assessed for hardness, weight fluctuation, thickness, friability, drug content homogeneity, and in vitro dissolution experiments. F6(IR) and F12(SR) were identified as the optimum formulations based on many assessment factors. The aforementioned buoyancy measurements indicate that F12 exhibits a greater total floating time compared to the other formulations. Formulations F6 (IR) and F12 (SR) exhibited the highest drug release within the specified timeframe. All formulations underwent drug release kinetics tests, including zero order, first order, Higuchi matrix, and Peppas model equations. The sustained release (SR) formulations exhibited zero order release with a super case II transport mechanism.