Post Marketing In-Vitro Relative Analysis of diverse brands of rosuvastatin calcium accessible in urban Karachi (Pakistan)

Abstract

Having a place with a class of medication known as "statins" Rosuvastatin calcium is an orally manufactured lipid lowering drug. It is another HMG-CoA reductase inhibitor that diminishes LDL and choestrol level. An amazing advantage hazard profile of Rosuvastatin makes it increasingly worthy to treat dyslipidemia. This statin is generally recommended in mix with different medications to treat hyperlipidemia. The point of this investigation was to set up pharmaceutical comparability among the brands accessible in Karachi Pakistan. Two distinct brands of Rosuvastatin Calcium proportional to Rosuvastatin tablets 5mg were incorporated. Six quality control parameters: weight variation, thickness test, hardness test, friability test, disintegration test, and dissolution test were performed through BP and USP monographs. All the test performed in this investigation were found under the limits. The examination recommends that both the brands of Rosuvastatin accessible in Karachi, Pakistan meet the determination for quality control investigation and were equivalent to each other.