Calendula Officinalis enhance the wound healing potential in diabetic rats

Saravanan VS; Kalpana Krishnaraju; Manimekalai Pichaivel; Krishnaraju Venkatesan; Premalatha Paulsamy; Divya Kuppan

Authors

Saravanan VS Erode College of Pharmacy, Veppampalayam, Erode, India
Kalpana Krishnaraju Erode College of Pharmacy, Veppampalayam, Erode, India
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamilanadu, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

C. officinalis, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

The goal of this study was to see how well Calendula.officinalis (C.officinalis) could treat dead space wounds in rats in vivo. On each axilla of diabetic rats, dead space incisions were created. For eight days, the rats were randomly assigned to one of three treatment groups (Group I: Normal saline; Group II: Diabetic control; Group III: Tannin). Animals were euthanized on day 10, and cotton pellets and granuloma tissues were carefully collected and processed for further estimates. Tissue breaking strength, dry and wet weight, and biochemical markers including hydroxyproline, hesosamine, and tissue protein were used to assess healing capacity. The extract was taken orally and had a favourable effect on the wound. The C.officinalis extract shows considerable wound healing activity in diabetic wounds, based on the preceding findings.