Role of Aloe Vera aqueous extract in dead space wound in diabetic rats

Manimekalai Pichaivel; Kalpana Krishnaraju; Saravanan VS; Premalatha Paulsamy; Divya Kuppan; Krishnaraju Venkatesan

Authors

Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamilanadu, India
Kalpana Krishnaraju Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Saravanan VS Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA

Keywords:

Aloe Vera, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

Physical impairments are frequently caused by wounds. Wound healing is the orderly evolution of a set of processes that restore the injured tissue integrity. Constipation, colitis, asthma, irritable bowel syndrome, diabetes, peptic ulcer, inflammation, heart burn, stress, and other ailments are treated using Aloe vera leaves pulp from Aloe arborescens species. The purpose of this study was to evaluate the effect of Aloe vera leaf pulp on wound healing activity using an oral route on a dead space wound model. On an excision wound model, Aloe vera leaf pulp was discovered to have a superior and faster wound healing effect. In the current study, in a dead space wound model, wet and dry granulation tissue weights, granulation tissue breaking strength, and hydroxyl proline, hexuronic acid, tissue protein, and lysyl oxidase content all increased statistically significantly.