Centella Asiatica L enhance wound healing potential in dead space wound in diabetic rats

Kalpana Krishnaraju; Saravanan VS; Krishnaraju Venkatesan; Manimekalai Pichaivel; Premalatha Paulsamy; Divya Kuppan

Authors

Kalpana Krishnaraju Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Saravanan VS Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

Centella asiatica, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

Centella asiatica (C.asiatica ) is a well-known medicinal herb used in Indian medicine to treat a variety of skin problems. The purpose of the research reported in this article was to assess the wound-healing capacity of the plant's ethanolic extract in diabetic rats. Wistar albino rats were used in the investigation, and dead space wounds were used as a model. When compared to controls, the extract of C.asiatica considerably enhanced wound breaking strength in wound models. In a dead space wound model, wet and dry granulation tissue weights, granulation tissue breaking strength, and hydroxyproline, hexuronic acid, tissue protein, and lysyl oxidase content all increased statistically significantly. In a rat model, the results showed that the leaf extract accelerates wound healing substantially.