Wound healing potential of Catharanthus Roseus on dead space wound in diabetic rats

Saravanan VS; Manimekalai Pichaivel; Krishnaraju Venkatesan; Kalpana Krishnaraju; Premalatha Paulsamy; Divya Kuppan

Authors

Saravanan VS Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Kalpana Krishnaraju Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

C. roseus, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

Catharanthus roseus L (C.roseus) is a plant that has traditionally been used to treat a wide range of illnesses, including diabetes. The researchers wanted to test if a Catharanthus flower extract might cure streptozotocin induced lesions in diabetic rat. Dead space incisions were made on the diabetic rats axillas. The rats were divided into three treatment groups at random for eight days (Group I: Normal saline; Group II: Diabetic control; Group III: C.roseus). On day 10, the animals were killed, cotton pellets and granuloma tissues were meticulously collected and processed for further analysis. Overall 18 rats were utilised in the experiment. During the trial, the C.roseus group had a substantial increase in dry and wet tissue weight when compared to the other groups. In addition, as compared to the control, C.roseus treatment dramatically enhanced Hydroxy proline, Hexosamines, Hexuronic acid, Tissue protein, and Lysyl oxidase. The increased hydroxyl proline content, as well as other important bio chemicals, support the use of C. roseus for topical wound healing treatment.