Astragalus membranaceus promotes bone formation in streptozotocin-induced diabetic rats

Krishnaraju Venkatesan; Kalpana Krishnaraju; Saravanan VS; Manimekalai Pichaivel; Premalatha Paulsamy; Divya Kuppan

Authors

Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Kalpana Krishnaraju Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Saravanan VS Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan Jkk Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

Astragalus membranaceus extract, Diabetic osteoporosis, streptozotocin

Abstract

In ovariectomized (OVX) rats, Astragalus membranaceus ethanol extract (AMEE), a traditional Asian herb, was shown to increase bone mineral density, biomechanical strength, and ash weight of the femur and tibia. The impact of AMEE on bone loss caused by diabetes is investigated in this study. The effect of AMEE on blood glucose, HBA1C levels, and bone mineral density was studied using a rat model. A total of twenty-four male Sprague Dawley rats were split into four groups (each with six rats): Normal control rats received saline (NC), diabetic control rats received saline (DC), diabetic rats received 1000 mg/kg of metformin (MET), and diabetic rats received 500 mg/kg of AMEE. Blood glucose, HBA1C levels, and bone mineral density were all improved after treatment with AMEE. These findings imply that AMEE may be more effective in preventing diabetes related bone loss.