Wound healing potential of achyranthes aspera on dead space wound in diabetic rats

Kalpana Krishnaraju; Krishnaraju Venkatesan; Saravanan VS; Manimekalai Pichaivel; Premalatha Paulsamy; Divya Kuppan

Authors

Kalpana Krishnaraju Erode College of Pharmacy, Veppampalayam, Erode, India
Krishnaraju Venkatesan Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA
Saravanan VS Erode College of Pharmacy, Veppampalayam, Erode, India
Manimekalai Pichaivel Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India
Premalatha Paulsamy King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia
Divya Kuppan JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India

Keywords:

A.aspera, Wound healing, Diabetic, Dead space wound, Granulation tissue, Streptozotocin

Abstract

The goal of this study is to see how effective Achyranthes Aspera (A.aspera) is at healing dead space wounds in diabetic rats. On each axilla of diabetic rats, dead space incisions were created. For eight days, the rats were randomly assigned to one of three treatment groups (Group I: Normal saline; Group II: Diabetic control; Group III: A.aspera). Animals were euthanized on day 10, cotton pellets and granuloma tissues were carefully collected and processed for further estimates. Overall, 18 rats were utilized in the experiment. During the trial, the A.aspera group had a substantial increase in dry and wet tissue weight when compared to the other groups. In addition, as compared to the control, A.aspera therapy dramatically enhanced Hydroxyproline, Hexosamines, Hexuronic acid, Tissue protein, and Lysyl oxidase. The use of A.aspera extract improves wound healing activity in diabetic rats, according to the results of this investigation. The phytoconstituents in A.aspera are responsible for the plant's wound healing ability.