Fenugreek [Trigonella foenum-graecum] linn- a reducer of glucose and lipid profile in diabetic subjects

Abstract

Back ground: Recently use of herbal medicines, have been considered as an alternative for therapeutic usage. Fenugreek (Trigonella foenum graecum Linn), used as traditional medicine and natural additive food, has been shown to exert significant antiatherogenic, antidiabetic, antianorexic, antioxidant, anticarcinogenic, antihyperlipidemic, galactogogue and anti-inflammatory effects in several human and animal models. Objective: Taking this lead, an evaluation was done for the effect of fenugreek on blood glucose and lipid profile in Type 2 diabetic subjects. Methodology: Forty diabetics, both sex (14 male and 26 female), of 1-5 years duration, on treatment with oral anti-diabetic drugs, without any complications were included in this open trial, conducted for a period of eight weeks. They were divided into two (20 in each) groups. First group were treated with 15 grams of Fenugreek seeds (5 grams in each pocket) in 3 divided doses per day after meals, along with their oral anti-diabetic drugs, while the second group were allowed to continue with regular oral anti-diabetic medications only, without fenugreek. Pre and post-test, fasting blood sugar, total cholesterol, triglycerides, low density, high density and very low-density cholesterol were taken.  Results: Statistical analysis showed significant reduction in blood sugar and lipid profile. Conclusion: Fenugreek supplementation with oral anti- diabetic drugs has produced significant fall in fasting blood sugar and modulations in lipid levels.